81 Life Sciences Breakthrough Prize Laureates

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81 Life Sciences Breakthrough Prize Laureates

YearCeremony locationLaureatesAffiliation (when awarded)Affiliation (current/last)Reasons
2013Geneva, SwitzerlandCornelia BargmannRockefeller University, USRockefeller University, US“For the genetics of neural circuits and behavior, and synaptic guidepost molecules.”
2013Geneva, SwitzerlandDavid BotsteinPrinceton University, USPrinceton University, US (Deceased)“For linkage mapping of Mendelian disease in humans using DNA polymorphisms.”
2013Geneva, SwitzerlandLewis C. CantleyWeill Cornell Medical College, USDana–Farber Cancer Institute, US“For the discovery of PI 3-Kinase and its role in cancer metabolism.”
2013Geneva, SwitzerlandHans CleversHubrecht Institute, NetherlandsHubrecht Institute, Netherlands“For describing the role of Wnt signaling in tissue stem cells and cancer.”
2013Geneva, SwitzerlandTitia de LangeRockefeller University, USRockefeller University, US“For research on telomeres, illuminating how they protect chromosome ends and their role in genome instability in cancer.”
2013Geneva, SwitzerlandNapoleone FerraraUniversity of California, San Diego, USUniversity of California, San Diego, US“For discoveries in the mechanisms of angiogenesis that led to therapies for cancer and eye diseases.”
2013Geneva, SwitzerlandEric S. LanderBroad Institute of MIT and Harvard, USBroad Institute, US“For the discovery of general principles for identifying human disease genes.”
2013Geneva, SwitzerlandCharles L. SawyersMemorial Sloan Kettering Cancer Center, USMemorial Sloan Kettering Cancer Center, US“For cancer genes and targeted therapy.”
2013Geneva, SwitzerlandRobert A. WeinbergMassachusetts Institute of Technology, USMassachusetts Institute of Technology, US“For characterization of human cancer genes.”
2013Geneva, SwitzerlandShinya Yamanaka (山中伸弥)Kyoto University, JapanKyoto University, Japan“For induced pluripotent stem cells.”
2013Geneva, SwitzerlandBert VogelsteinJohns Hopkins University, USJohns Hopkins University, US“For cancer genomics and tumor suppressor genes.”
2014Mountain View, USJames P. AllisonMD Anderson Cancer Center, USMD Anderson Cancer Center, US“For the discovery of T cell checkpoint blockade as effective cancer therapy.”
2014Mountain View, USMahlon DeLongEmory University, USEmory University, US“For defining the interlocking circuits in the brain that malfunction in Parkinson’s disease.”
2014Mountain View, USMichael N. HallUniversity of Basel, SwitzerlandUniversity of Basel, Switzerland“For the discovery of Target of Rapamycin (TOR) and its role in cell growth control.”
2014Mountain View, USRobert LangerMassachusetts Institute of Technology, USMassachusetts Institute of Technology, US“For discoveries leading to the development of controlled drug-release systems and new biomaterials.”
2014Mountain View, USRichard P. LiftonYale University, USRockefeller University, US“For the discovery of genes and biochemical mechanisms that cause hypertension.”
2015Mountain View, USAlim Louis BenabidJoseph Fourier University, FranceJoseph Fourier University, France“For the discovery and development of deep brain stimulation (DBS), which has revolutionized the treatment of Parkinson’s disease.”
2015Mountain View, USC. David AllisRockefeller University, USRockefeller University, US (Deceased)“For the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression.”
2015Mountain View, USVictor AmbrosUniversity of Massachusetts Medical School, USUniversity of Massachusetts Medical School, US“For the discovery of a new world of genetic regulation by microRNAs.”
2015Mountain View, USGary RuvkunMassachusetts General Hospital & Harvard, USHarvard Medical School, US“For the discovery of a new world of genetic regulation by microRNAs.”
2015Mountain View, USJennifer DoudnaUniversity of California, Berkeley, USUniversity of California, Berkeley, US“For harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes.”
2015Mountain View, USEmmanuelle CharpentierHelmholtz Centre for Infection Research, GermanyMax Planck Unit for the Science of Pathogens, Germany“For harnessing an ancient mechanism of bacterial immunity into a powerful and general technology for editing genomes.”
2016Mountain View, USEdward BoydenMassachusetts Institute of Technology, USMassachusetts Institute of Technology, US“For the development and implementation of optogenetics.”
2016Mountain View, USKarl DeisserothStanford University, USStanford University, US“For the development and implementation of optogenetics.”
2016Mountain View, USJohn HardyUniversity College London, UKUniversity College London, UK“For discovering mutations in the Amyloid Precursor Protein (APP) gene that cause early onset Alzheimer’s disease.”
2016Mountain View, USHelen HobbsUniversity of Texas Southwestern Medical Center, USUT Southwestern Medical Center, US“For the discovery of human genetic variants that alter the levels and distribution of cholesterol.”
2016Mountain View, USSvante PääboMax Planck Institute for Evolutionary AnthropologyMax Planck Institute, Germany“For pioneering the sequencing of ancient DNA and ancient genomes.”
2017Mountain View, USStephen J. ElledgeHarvard Medical School, USHarvard Medical School, US“For elucidating how eukaryotic cells sense and respond to damage in their DNA.”
2017Mountain View, USHarry F. NollerUniversity of California, Santa Cruz, USUniversity of California, Santa Cruz, US“For discovering the centrality of RNA in the molecular machinery of protein synthesis.”
2017Mountain View, USRoeland NusseStanford University, USStanford University, US“For pioneering research on the Wnt pathway, a crucial signaling system in development and cancer.”
2017Mountain View, USYoshinori Ohsumi (大隅良典)Tokyo Institute of Technology, JapanTokyo Institute of Technology, Japan“For elucidating autophagy, the recycling system that cells use to generate nutrients.”
2017Mountain View, USHuda ZoghbiBaylor College of Medicine, USBaylor College of Medicine, US“For discoveries of the genetic causes and biochemical mechanisms of spinocerebellar ataxia and Rett syndrome.”
2018Mountain View, USJoanne ChorySalk Institute for Biological Studies, USSalk Institute for Biological Studies, US“For discovering how plants optimize their growth, development, and cellular structure in response to light.”
2018Mountain View, USDon W. ClevelandUniversity of California, San Diego, USUniversity of California, San Diego, US“For elucidating the molecular pathogenesis of a type of inherited ALS.”
2018Mountain View, USKazutoshi Mori (森和俊)Kyoto University, JapanKyoto University, Japan“For elucidating the unfolded protein response, a cellular quality-control system.”
2018Mountain View, USPeter WalterUniversity of California, San Francisco, USAltos Labs, US“For elucidating the unfolded protein response, a cellular quality-control system.”
2018Mountain View, USKim NasmythUniversity of Oxford, UKUniversity of Oxford, UK“For elucidating the sophisticated mechanism that mediates the perilous separation of duplicated chromosomes during cell division.”
2019Mountain View, USC. Frank BennettIonis Pharmaceuticals, USIonis Pharmaceuticals, US“For the development of an effective antisense oligonucleotide therapy for spinal muscular atrophy.”
2019Mountain View, USAdrian R. KrainerCold Spring Harbor Laboratory, USCold Spring Harbor Laboratory, US“For the development of an effective antisense oligonucleotide therapy for spinal muscular atrophy.”
2019Mountain View, USAngelika AmonMassachusetts Institute of Technology, USMassachusetts Institute of Technology, US (Deceased)“For determining the consequences of aneuploidy, an abnormal chromosome number.”
2019Mountain View, USXiaowei ZhuangHarvard University, USHarvard University, US“For discovering hidden structures in cells by developing super-resolution imaging.”
2019Mountain View, USZhijian ChenUT Southwestern Medical Center, USUT Southwestern Medical Center, US“For elucidating how DNA triggers immune and inflammatory responses from within the cell.”
2020Mountain View, USJeffrey M. FriedmanRockefeller University, USRockefeller University, US“For the discovery of a new endocrine system through which adipose tissue signals the brain to regulate food intake.”
2020Mountain View, USF. Ulrich HartlMax Planck Institute of Biochemistry, GermanyMax Planck Institute, Germany“For discovering functions of molecular chaperones in mediating protein folding.”
2020Mountain View, USArthur L. HorwichYale School of Medicine, USYale School of Medicine, US“For discovering functions of molecular chaperones in mediating protein folding.”
2020Mountain View, USDavid JuliusUniversity of California, San Francisco, USUniversity of California, San Francisco, US“For discovering cellular mechanisms that produce pain sensations from heat, cold, and chili peppers.”
2020Mountain View, USVirginia Man-Yee LeeUniversity of Pennsylvania, USUniversity of Pennsylvania, US“For discovering TDP-43 protein aggregates in frontotemporal dementia and ALS.”
2021Los Angeles, US (Virtual)David BakerUniversity of Washington, USUniversity of Washington, US“For developing technology that allowed the design of macromolecular proteins never before seen in nature.”
2021Los Angeles, US (Virtual)Catherine DulacHarvard University, USHarvard University, US“For deconstructing the complex behavior of parenting to the level of brain cells and wiring.”
2021Los Angeles, US (Virtual)Dennis LoThe Chinese University of Hong KongThe Chinese University of Hong Kong“For discovering that fetal DNA is present in maternal plasma and can be used for non-invasive prenatal testing.”
2021Los Angeles, US (Virtual)Richard J. YouleNational Institutes of Health, USNational Institutes of Health, US“For elucidating a quality control pathway that clears damaged mitochondria and thereby protects against Parkinson’s disease.”
2022Los Angeles, US (Virtual)Jeffery W. KellyScripps Research Institute, USScripps Research Institute, US“For elucidating the molecular basis of neurodegenerative and cardiac transthyretin amyloid diseases.”
2022Los Angeles, US (Virtual)Katalin KarikóBioNTech & University of Pennsylvania, USUniversity of Szeged, Hungary“For engineering modified RNA technology that enabled the rapid development of effective COVID-19 vaccines.”
2022Los Angeles, US (Virtual)Drew WeissmanUniversity of Pennsylvania, USUniversity of Pennsylvania, US“For engineering modified RNA technology that enabled the rapid development of effective COVID-19 vaccines.”
2022Los Angeles, US (Virtual)Shankar BalasubramanianUniversity of Cambridge, UKUniversity of Cambridge, UK“For the development of robust, next-generation DNA sequencing methodologies.”
2022Los Angeles, US (Virtual)David KlenermanUniversity of Cambridge, UKUniversity of Cambridge, UK“For the development of robust, next-generation DNA sequencing methodologies.”
2022Los Angeles, US (Virtual)Pascal MayerAlphanosos, FranceAlphanosos, France“For the development of robust, next-generation DNA sequencing methodologies.”
2023Los Angeles, USClifford P. BrangwynnePrinceton University, USPrinceton University, US“For discovering a fundamental mechanism of cellular organization mediated by phase separation of proteins and RNA into membraneless liquid droplets.”
2023Los Angeles, USAnthony A. HymanMax Planck Institute of Molecular Cell Biology and GeneticsMax Planck Institute, Germany“For discovering a fundamental mechanism of cellular organization mediated by phase separation of proteins and RNA into membraneless liquid droplets.”
2023Los Angeles, USDemis HassabisGoogle DeepMind, UKGoogle DeepMind, UK“For developing AlphaFold, which accurately predicts the 3D structure of proteins.”
2023Los Angeles, USJohn JumperGoogle DeepMind, UKGoogle DeepMind, UK“For developing AlphaFold, which accurately predicts the 3D structure of proteins.”
2023Los Angeles, USEmmanuel MignotStanford University School of Medicine, USStanford University, US“For discovering that narcolepsy is caused by the loss of a small population of brain cells that make a wake-promoting substance.”
2023Los Angeles, USMasashi Yanagisawa (柳沢正史)University of Tsukuba, JapanUniversity of Tsukuba, Japan“For discovering that narcolepsy is caused by the loss of a small population of brain cells that make a wake-promoting substance.”
2024Los Angeles, USCarl H. JuneUniversity of Pennsylvania, USUniversity of Pennsylvania, US“For the development of chimeric antigen receptor T-cell (CAR-T) therapy for leukemia.”
2024Los Angeles, USMichel SadelainMemorial Sloan Kettering Cancer Center, USMemorial Sloan Kettering Cancer Center, US“For the development of chimeric antigen receptor T-cell (CAR-T) therapy for leukemia.”
2024Los Angeles, USSabine HadidaVertex Pharmaceuticals, USVertex Pharmaceuticals, US“For developing combination therapies that repair the defective chloride channel protein in cystic fibrosis.”
2024Los Angeles, USPaul NegulescuVertex Pharmaceuticals, USVertex Pharmaceuticals, US“For developing combination therapies that repair the defective chloride channel protein in cystic fibrosis.”
2024Los Angeles, USFred Van GoorVertex Pharmaceuticals, USVertex Pharmaceuticals, US“For developing combination therapies that repair the defective chloride channel protein in cystic fibrosis.”
2024Los Angeles, USThomas GasserHertie Institute for Clinical Brain Research, GermanyUniversity of Tübingen, Germany“For identifying the most common genetic risk factors for Parkinson’s disease.”
2024Los Angeles, USEllen SidranskyNational Human Genome Research Institute, USNational Institutes of Health, US“For identifying the most common genetic risk factors for Parkinson’s disease.”
2024Los Angeles, USAndrew SingletonNational Institute on Aging, USNational Institutes of Health, US“For identifying the most common genetic risk factors for Parkinson’s disease.”
2025Los Angeles, US– (List Ongoing for 2025/2026 updates)Updated per cohort releases in medical genomics and cellular pathways.
2026Los Angeles, USJean BennettUniversity of Pennsylvania, USUniversity of Pennsylvania, US“For developing the first gene replacement therapy approved by the U.S. FDA, targeting rare inherited blindness.”
2026Los Angeles, USKatherine HighUniversity of Pennsylvania, USAskBio, US“For developing the first gene replacement therapy approved by the U.S. FDA, targeting rare inherited blindness.”
2026Los Angeles, USAlbert MaguireUniversity of Pennsylvania, USUniversity of Pennsylvania, US“For developing the first gene replacement therapy approved by the U.S. FDA, targeting rare inherited blindness.”
2026Los Angeles, USStuart H. OrkinHarvard Medical School, USHarvard Medical School, US“For discoveries that led to gene-editing treatments for sickle cell disease and beta-thalassemia.”
2026Los Angeles, USSwee Lay TheinNational Institutes of Health, USNational Institutes of Health, US“For discoveries that led to gene-editing treatments for sickle cell disease and beta-thalassemia.”
2026Los Angeles, USRosa RademakersVIB-UAntwerp Center for Molecular NeurologyVIB-UAntwerp, Belgium“For uncovering a major genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.”
2026Los Angeles, USBryan TraynorNational Institute on Aging, USNational Institutes of Health, US“For uncovering a major genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.”